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You are watching: What does clinical correlation recommended mean


In a brain MRI report, the complying with words regularly appear: “clinical correlation is recommended”. These words signify that insufficient clinical details was provided, or that an unforeseen finding top top the MRI should be assessed clinically. “Clinical correlation is recommended” is less usual in a report about a solitary gene or straightforward gene panel. This is because the an extremely act of bespeak the check conveys lot of what is important about the clinical situation, and only hardly ever is further information needed.

Genetics labs are relocating into brand-new territory together they adopt next-generation genomic sequencing. When relocating beyond solitary gene exam and basic panels, an ext clinical correlation is needed. The complexity of translate becomes similar to a mind MRI, only much more so.

In one exome, hundreds of variants are found. Even after comparing to other household members, and also using estimates of variant pathogenicity, countless genes need to be considered. Sometimes clinical correlation can be as simple as making use of the key clinical finding, assuming the you recognize which recognize is key. However sometimes the situation is an ext complicated: variants are uncovered in a gene the hadn"t been thought about clinically, or 2 genes are required to define the clinical picture, and more clinical correlation is needed.

For mind MRI scans, this clinical correlation is institutionalized as neuroradiology rounds organized several times a main by numerous neurology inpatient services. Just how should the analogous clinical correlation because that genomic interpretation be structured?

The main point principle the clinical correlation should be that comprehensive information around the patient"s findings, the phenotype, is merged with comprehensive information in the annotated different table, the genotype. Because this is excellent in the more comprehensive context that considering all recognized phenotypes, the an outcome is a “genome–phenome” analysis.

In what venue should the “aha” of this clinical correlation occur? each venue has plusses and minuses:

Hybrid: Genome and phenome expertise have the right to be united by having actually meetings of clinical and also genomic experts comparable to neuroradiology rounds or tumor boards. This hybrid venue requires delays and overhead of big teams, but unites deep field of expertise in both genome and also phenome. The efficacy the the process would count on the quality and efficiency that this communication between clinical and genomic experts.

Each of these models involves substantial training or overhead to integrate genome and phenome information. However, the capacity to do so is greatly facilitated by software tools that assist combine genomic and also clinical expertise. Such software application has arisen in a stepwise process and is currently in use amongst clinicians and also lab experts:

Communication boosts as its power is demonstrated: once clinicians are part of the process of genome interpretation, they watch the prestige of providing robust phenotypic information and helping curate information about known phenotypes. See the difference between “garbage in, garbage out” and also “quality in, top quality out” is worth a thousands exhortations.

As labs go with the cultural shift from single gene tests come genomic analysis, that is critical to emphasis on the process of clinical correlation, the to meet in which it is done, and also the tools that can assist get clinical and also genomic specialists “on the same page”.


Funding source

Some the the work-related on i beg your pardon this comment is based has been supported by NIH grants and contracts come the writer (National Library of medication HHSN276201000026C and also 5R44LM011585, and also National person Genome study Institute 1R43HG006974 and also 2R42HG006974).


Conflict the interest

The author is employed by SimulConsult, i m sorry produces genome analysis software.

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Segal M, Leber S “The influence of computer resources on kid neurology” in Swaiman KF et al. “Pediatric Neurology: Principles and also Practice”, fifth edition, Mosby, 2012.