There is an interaction in between the two and also taking both should only be excellent under the supervision of your doctor.

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At a glance

Tylenol PM consists of diphenhydramine, a sedating first-generation antihistamine. Merged use of diphenhydramine and Xanax (alprazolam) can an outcome in additive side effects, consisting of sedation, dizziness, and in an ext severe cases, respiratory tract depression.



In general, it isn"t encourage to take it Tylenol PM and Xanax (alprazolam) together since both save sedating, CNS depressant drugs.

Xanax includes alprazolam, a rapid-acting benzodiazepine, and Tylenol PM contains two active ingredients:


Diphenhydramine is the ingredient in Tylenol afternoon that causes sedation. It is likewise the energetic ingredient in Benadryl.

The usage of any kind of benzodiazepine (including alprazolam) v diphenhydramine can an outcome in additive side effects.<1><2>

These additive effects include:

SedationLightheadednessDry mouthDrowsinessDizzinessRespiratory depression

Since coadministration that Tylenol PM and also Xanax can an outcome in a potentiation of side effects, caution is recommended v the combination.

Interaction Explained

Most virtual drug interaction checkers (including our own) will certainly list a similar precaution v the an unified use of Xanax and Tylenol PM. Ours, which supplies the Drugbank database, claims the following:

The hazard or severity the adverse results can be enhanced when Alprazolam is an unified with Diphenhydramine .PharmacistAnswers communication Checker (DrugBank)

Both alprazolam and also diphenhydramine have actually what is well-known as a CNS (central nervous system) depressant effect.

The CNS depressant effects are much stronger through alprazolam when compared to diphenhydramine, but because both have them, the effects will likely be an ext pronounced when used together.<3>

So, what precisely happens with CNS depressants?

As a general overview, CNS depressants, which have the right to work through a range of mechanisms, inhibit/suppress mind activity, which have the right to have a selection of effects.<4>

The most typical effects the CNS depression is sedation and drowsiness, i beg your pardon is why they are typically used for anxiety and for sleep.

However, once high sheep of CNS depressants are used, much more severe side effects can occur, including:

Decreased heart rateReduced consciousnessReduced respiration (i.e. Respiratory tract depression)

Combining CNS depressants is just one of the many common causes of overdose death, which usually happens together a result of respiratory tract depression. Opioids, benzodiazepines, and alcohol are all solid CNS depressants.<5>

Now, diphenhydramine is not a solid CNS depressant when compared to other classes of medicine (like benzodiazepines) but does commonly cause sedation (which is why that is together a typically used ingredient in over the counter sleep aids).

It has only been connected with respiratory depression in instances of overdose.

If you combine diphenhydramine (from Tylenol PM) with Xanax (alprazolam), you most likely will experience boost in sedation and also drowsiness.

It would be uncommon that you have much more serious side effects, yet the hazard is absolutely still there (especially if you were to mix both with various other depressants, prefer alcohol).

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Your medical professional may recommend the occasional usage of Tylenol PM, also if you take it alprazolam, in details situations. However, for all the reasons declared above, castle shouldn"t be provided consistently together.