Diphenhydramine as an adjunct to sedation because that colonoscopy: a double-blind randomized, placebo-controlled study
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Intravenous benzodiazepines in combination with opiates are supplied to accomplish moderate sedation because that colonoscopy. Return effective, this agents have potential disadvantage effects, such as respiratory depression and also hypotension. Diphenhydramine hydrochloride possesses central nervous system depressant effects that about theory could provide a synergistic result for sedating patients.

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The objective to be to evaluate the efficacy of including diphenhydramine hydrochloride as an adjunct to boost sedation and to mitigate the lot of standard sedatives used during colonoscopy.
The examine group comprised 270 patients undergoing screening/diagnostic/therapeutic colonoscopy to be enrolled.
Patients to be randomized to get either 50 mg the diphenhydramine or placebo, given intravenously 3 minute before starting conscious sedation v intravenous midazolam and also meperidine.
The main outcome measure up was anesthetic impact as assessed by the endoscopy team and also by the patient; amount of adjunctive sedatives to attain adequate sedation.
Of 270 patients, data to be analyzed because that 258 patients, v 130 patient in the diphenhydramine group and also 128 patients in the placebo group. There was a 10.1% palliation in meperidine usage and also 13.7% reduction in midazolam intake in favor of the diphenhydramine group. The median evaluation scores as judged by the faculty, the fellows, and the registered nurses were statistically far-ranging in donate of the diphenhydramine group. In addition, patient scores for overall sedation and pain level favored the group that got diphenhydramine.
Intravenous diphenhydramine given before initiation of standard sedation provides a significant benefit to mindful sedation for patients experience colonoscopy.
in: Hardman J.G. Limbird L.E. Goodman and also Gilman"s the pharmacological communication of therapeutics. 10th ed. McGraw-Hill, brand-new York2001: 651-657
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